Solutions to Enable Your COVID-19 Research

COVID-19 Research

While the COVID-19 global pandemic continues to evolve, we at BD Biosciences believe that scientific research is critical to better understanding and ultimately battling this disease. Now more than ever, BD Biosciences is committed to being your partner and providing you with the tools and support required to enable your COVID-19 research.

We provide a comprehensive portfolio of research tools to facilitate discovery in the following areas of COVID-19 research:

  • Viral immune response
  • Cytokine analysis
  • Vaccine research
  • Biomarkers and therapeutics

BD Biosciences’ portfolio of research tools

Navigate this site to learn more about BD Biosciences' solutions and their applications in COVID-19 research. All products mentioned on these pages are for research use only, with the exception of the BD FACSLyric? Flow Cytometer, which is an IVD instrument that can also be used in research. Its use in COVID-19 is for research purposes only.

For information on BD’s comprehensive COVID-19 response efforts—including product availability, status of BD operations and business continuity planning—visit bd.com/COVID-19

Intro to COVID-19

COVID-19, or Coronavirus Disease 2019, is caused by the SARS-CoV-2 virus. SARS-CoV-2 is a novel virus belonging to the Coronavirus family, which includes less pathogenic strains responsible for the common cold, as well as the viruses responsible for SARS and MERS. It is genetically related to the coronavirus responsible for the SARS outbreak in 2003.

Key structural proteins of the virus include the spike (S) glycoprotein, the envelope (E) protein and the matrix (M) transmembrane glycoprotein. S protein is responsible for receptor binding, membrane fusion and hemagglutinin activity, and is a target for eliciting host neutralizing antibody. E protein is important for virus infectivity and interacts with the M protein to form the viral envelope.

Coronaviruses and the Immune System

As the COVID-19 pandemic continues to affect the world’s population, a more detailed understanding of host immune responses may help provide a clearer picture of how the pathogen causes disease in some individuals while most infected people may only show mild or no symptoms at all. Also, an understanding of immune correlates (potential biomarkers) of protection as well as long-term immune memory from convalescent individuals may aid in the design of prophylactic and therapeutic measures for future outbreaks of similar or other coronaviruses.

Scientific Resources

Immune Response to COVID-19

As the COVID-19 pandemic continues to spread worldwide, there is a pressing need to understand the biological mechanisms determining disease progression and severity. Early research studies have reported dysfunctional immune responses and alterations in the immune cell composition in COVID-19 patients. The extent of the immune dysregulation appears to correlate with the severity of COVID-19 disease. A deeper understanding of the interactions between SARS-CoV-2 and the host immune system will be required to further understand the pathogenesis of this disease and identify biomarkers that may potentially, be used to predict, monitor and/or prevent COVID-19 progression.

Webinar: Monitoring the Immune System to Fight COVID-19

An overview of preliminary studies documenting the immunological changes observed in COVID-19 patients was recently presented by Dr. Maurice O’Gorman and Dr. Andrea Cossarizza.

View Webinar

Research Highlights

Reference Sample Size Comparative Analysis Immunological Changes
Wang et al. The Laboratory Test and Host Immunity of COVID-19 Patients with Different Severity of Illness JCI Insight. 2020 April.

PMID: 32324595
65 COVID?19 patients Extremely Severe vs Severe vs Moderate Cases Total lymphocytes, total CD4+ and CD8+ T cells, B cells (absolute count)
Total T cells, CD4+ cells (%)
CD45RA+ Naïve Tregs (%)
CD4+ CD28+ and CD8+ CD28+ T cells (%)
CD86+ Dendritic cells (%)
CD4+ CD45RO+ memory T cells (%)
HLA-DR+ activated CD4+ and CD8+ T cells (%)
NK cells (%)
PD-1+ exhausted CD4+ and CD8+ T cells (%)
CD4+ and CD8+ T cells producing IFN-γ (%)
Serum amounts of IL-6 and IL-10 (pg/mL)
Cheng et al. Clinical and Immunologic Features in Severe and Moderate Coronavirus Disease 2019. J Clin Invest. 2020 May.

PMID: 32217835
21 COVID?19 patients Severe vs Moderate Cases Total lymphocytes, CD4+ and CD8+ T cells (absolute count)
Total B cells (%)
CD45RA+ Naïve Tregs (%)
CD4+ T cells producing IFN-γ (%)
Serum amounts of IL-6, IL-10, TNF, IL-2R (pg/mL)
Qin et al. Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis. 2020 March.

PMID: 32161940
452 COVID?19 patients Severe vs Moderate Cases Total lymphocytes, total T cells, CD4+ T cells (absolute count)
CD4+ cells (%)
CD4+ CD45RA+ naïve T cells (%)
CD8+ CD28+ cells (%)
Tregs (%)
CD4+ CD45RO+ memory T cells (%)
Serum amounts of TNF, IL-2R, IL-10, IL-6, IL-8 (pg/mL)
Zheng et al. Functional Exhaustion of Antiviral Lymphocytes in COVID-19 Patients. Cell Mol Immunol. 2020 May.

PMID: 32203188
68 COVID?19 patients Severe vs Moderate Cases Total lymphocytes, CD8+ T cells and NK cells (absolute count)
CD8+ T cells and NK cells expressing CD107a (%)
CD8+ T cells and NK cells producing GZMB,
IFN-γ, IL-2 and TNF (%)
NKG2A+ Exhausted CD8+ T cells and NK cells (%)
Zheng et al. Elevated Exhaustion Levels and Reduced Functional Diversity of T Cells in Peripheral Blood May Predict Severe Progression in COVID-19 Patients. Cell Mol Immunol. 2020 May.

PMID: 32203186
6 healthy controls
16 COVID?19 patients
Severe vs Moderate vs Healthy Cases CD4+ T cells producing IFN-α or TNF (%)
Polyfunctional CD8+ T cells producing IFN-γ, IL-2 and TNF (%)
HLA-DR+ activated CD8+ T cells (%)
PD-1+ CTLA-4+ TIGIT+ exhausted CD8+ T cells (%)

Zhou et al. Pathogenic T Cells and Inflammatory Monocytes Incite Inflammatory Storm in Severe COVID-19 Patients. Natl Sci Rev. 2020 March.

PMCID: PMC7108005

33 COVID?19 patients ICU vs No ICU Care Total T cells, CD4+ and CD8+ T cells, monocytes, NK cells (absolute count)
PD-1+TIM-3+ exhausted CD4+ and CD8+ T cells (%)
CD4+ T cells producing IL-6 and GM-CSF (%)
CD14+CD16+ monocytes producing IL-6 and GM-CSF (%)
Huang et al. Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China. Lancet. 2020 February.

PMID: 31986264
41 COVID?19 patients ICU vs No ICU Care Serum amounts of IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IP-10, MCP-1, G-CSF, GM-CSF, IFN-γ, TNF (pg/mL)
Diao et al. Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19). Front Immunol. 2020 May.

PMID: 32425950
40 healthy subjects
522 COVID?19 patients
ICU vs No ICU Care Total T cells, CD4+ and CD8+ T cells (absolute count)
PD-1+ exhausted CD4+ and CD8+ T cells (%)
Serum amounts of IL-6, IL-10, TNF (pg/mL)
Evangelos J et al. Complex Immune Dysregulation in COVID-19 Patients With Severe Respiratory Failure. Cell Host Microbe. 2020 April.

PMID: 32320677
54 COVID?19 patients Macrophage Activated Syndrome vs Dysregulated Immune Response vs Intermediate Immune Response Total CD4+ and CD8+ T cells, NK and B cells (absolute count)
HLA-DR expression on monocytes (absolute number of molecules/cell)
Neutrophils and macrophages (absolute count)
Serum amounts of IL-6 (pg/mL)
De Biasi et al. Marked T Cell Activation, Senescence, Exhaustion and Skewing Towards TH17 in Patients with Covid-19 Pneumonia. Research Square doi: 10.21203/rs.3.rs-23957/v1. (Pre-print)* 20 healthy subjects
21 COVID?19 patients
COVID?19 Patients vs Healthy Subjects CD8+ naïve and central memory T cells (%)
CD4+ and CD8+ TEMRA (%)
HLA-DR+ CD38+ activated CD4+ and CD8+ T cells (%)
PD-1+ CD57+ exhausted/senescent CD4+ and CD8+ T cells (%)
Naïve Tregs (%)
CD4+ and CD8+ T cells expressing CD107a (%)
CD8+ T cells producing IL-2 or IL-17 (%)
CD4+ T cells producing IL-2, IFN-α , TNF, or IL-17 (%)
Polyfunctional CD4+ T cells producing IL-2 and IL-17 (%)
Serum amounts of CXCL6, IFN-γ, Galectin-1, -3, -9, IL-1α, IL-4, IL-6, IL-7, IL-8, IL-10, IL-15, IL-17, MICA, MIP-2 (CXCL2), CCL2, CCL3, CCL4, TNF (pg/mL)

*Preprint report. This study has not undergone peer-review and should not be considered conclusive, used to inform clinical practice, or referenced as validated information.

The information on COVID-19 presented in the above table is relevant as of May 2020.

The studies reported here have not been independently validated by BD.
All BD reagents used in these studies are for Research Use Only. Not for use in diagnostic or therapeutic procedures.

Application Data

BD Biosciences enables COVID-19 research by providing solutions for a comprehensive immunophenotypic, functional and transcriptional analysis of immune cells.

Flow Cytometry

  • Assessment of immunophenotypic and functional changes in cells of the innate (e.g., monocytes, NK and dendritic cells) and adaptive (e.g., T and B cells) immune system
  • Measurement of cytokines responsible for or associated with cytokine release syndrome
  • Functional assays to assess antigen-specific T cell responses to viral epitopes

Fluorescence-Activated Cell Sorting

  • Purification of antigen-specific T or B cells for vaccine efficacy testing or generation of neutralizing monoclonal antibodies
  • Purification of immune cells of interest for downstream single-cell multiomic analysis

Single-Cell Multiomics

  • Profiling immune cells of interest via targeted or whole transcriptome analysis
  • Analysis of T or B cell receptor repertoire and assessment of cell clonality
  • Enhanced immune cell characterization and signature discovery through simultaneous analysis of protein and mRNA

View product information, application data and scientific resources for assays performed on healthy human or murine cells that can also be potentially applicable to COVID-19 research.

Technology Application Description
Flow cytometry Immunophenotyping Dried antibody cocktail for immunophenotypic characterization of human naïve, memory and effector T cells See Product Description
Dried antibody cocktail for immunophenotypic characterization of human regulatory T cells See Product Description
Dried antibody cocktail for immunophenotypic characterization of human monocytes See Product Description
Assessment of markers associated with T cell exhaustion Download Data Sheet
Immunophenotypic characterization of human NK cells View Webinar
Download Data Sheet
Immunophenotypic characterization of human B cells Download Data Sheet
Immunophenotypic characterization of murine dendritic cells Download Data Sheet
Broad immunophenotypic characterization of major human immune cell lineages Download Data Sheet
Broad immunophenotypic characterization of major murine immune cell lineages Download Data Sheet
Functional assays Proliferation, degranulation and intracellular cytokine analysis to assess CD8+ T cell activation Download Data Sheet
Apoptosis, degranulation and intracellular cytokine analysis to assess NK cell cytotoxicity Download Data Sheet
Intracellular cytokine analysis to assess the response of human dendritic cells to Toll-like Receptor agonists Download Data Sheet
Quantitation of Th1/Th2/Th17 cytokines produced by activated T cells using BD® Cytometric Bead Array (CBA) Download Data Sheet
Cell sorting and single-cell multiomics Deep cell characterization and cell signature discovery Identification of immunophenotypic and molecular signatures of chronically stimulated human T cells Download Scientific Poster
View Webinar
Workflow for discovery and confirmation of cell signatures defining human innate lymphoid cell subsets Download Data Sheet
View Webinar
Deep characterization of human regulatory T cells Download Data Sheet

Reagent Solutions

During this challenging time, researchers at the forefront of COVID-19 research need tools to power deeper cellular analysis. BD Biosciences research reagents include innovative dyes and a broad portfolio of human-specific antibodies to deliver more resolution and flexibility for experimental design, saving valuable samples and accelerating the time to critical insights.

Optimized Panels, Kits and Assays

Readily available optimized antibody cocktails, gene panels, kits and recommended multicolor flow cytometry panels shown in the tables below can help expedite experiments relevant to COVID-19 research.

Research Area Research Application Product Solution(s)
Viral Immune Response Identification of naïve and different memory T cell subsets in human whole blood BD Horizon? Dri Memory T Cell *
Identification of naïve and different effector regulatory T cell (Treg) subsets in human whole blood BD Horizon? Dri Treg Cell*
Identification of classical (M1), intermediate (M2) and non-classical (M3) monocyte subsets in human whole blood BD Horizon? Dri MonoSet Panel*
Targeted human immune gene panel (399 genes) relevant to phenotyping human immune cells BD Rhapsody™ Human Immune Response Panel
Targeted mouse immune gene panel (397 genes) relevant to phenotyping mouse immune cells BD Rhapsody™ Mouse Immune Response Panel
Targeted human T cell gene panel (259 genes) relevant to T cell biology BD Rhapsody™ Human T-Cell Expression Panel
Whole Transcriptome Analysis (WTA) enables identification of the most differentially expressed genes in your samples. The WTA data can be used for cell type identification and to construct a targeted panel tailored for your samples of interest BD Rhapsody™ WTA Reagent Kit 4 Pack
Cytokine Analysis Cytometric bead array to measure human cytokine(s) in serum, plasma and cell culture supernatant samples BD® CBA Human Inflammatory Cytokine Kit BD® CBA Human Th1/Th2 Cytokine Kit BD® CBA Human Th1/Th2 Cytokine Kit II BD® CBA Human Th1/Th2/Th17 Cytokine Kit
Vaccine Research
Biomarkers
Therapeutics
Detection of T and B cell clonotypes in samples of interest Validated V(D)J CDR3 protocol that
works with BD Rhapsody™
Targeted Panels, Sample Multiplexing
Kit, and BD® AbSeq Antibodies

*Please contact your sales representative to request a quote.

Research Area Research Application Recommended Research Panel
Viral Immune Response Assess the expression of multiple T cell inhibitory receptors
(PD-1, TIM-3, LAG-3, CTLA-4, BTLA, TIGIT) on naïve and
different memory T cell subsets
T Cell Exhaustion Panel
Marker Dye Clone Cat. No
CD3 PerCP-Cy5.5 UCHT1 560835
CD4 APC-R700 RPA-T4 564975
CD8 APC-H7 SK1 560179
CD45RA BV650 HI100 563963
CD197 (CCR7) FITC 150503 561271
CD95 BV480 DX2 746675
TIGIT BV421 741182 747844
CD152 (CTLA-4) PE BNI3 555853
CD223 (LAG-3) Alexa Fluor® 647 T47-530 565716
CD272 (BTLA) BV605 J168-540 743986
CD279 (PD-1) PE-Cy7 EH12.1 561272
CD366 (TIM-3) BV786 7D3 742857
Viral Immune Response Identification of T helper cell (Th) subsets (Th1, Th2, Th17, Th22),
follicular T helper cell (Tfh) subsets, regulatory T cell (Treg)
subsets, and follicular regulatory T cell (Tfr) subsets
T Cell Subset Panel
Marker Dye Clone Cat. No
Live/Dead 7-AAD N/A 559925
CD3 Alexa Fluor® 700 UCHT1 557943
CD4 APC-H7 SK3 641398
CD45RA BV605 HI100 562886
CD127 BV711 HIL-7R-M21 563165
CD25 BB515 2A3 564467
CD183 (CXCR3) PE-Cy7 1C6/CXCR3 560831
CD185 (CXCR5) BV480 RF8B2 566142
CD194 (CCR4) BV421 1G1 562579
CD196 (CCR6) BV786 11A9 563704
CD294 (CRTH2) PE BM16 563665
CCR10 APC 1B5 564771

BD Biosciences also offers a large and diverse portfolio of high-quality reagents to meet your specific experimental needs and enables the optimization and design of your own assay. Explore the availability of additional reagents.

Immunophenotyping and Cell Sorting

The immune response to a virus such as SARS-CoV-2 can be tracked in the blood. Multicolor flow cytometry is one of the most powerful tools with which to identify, for example, alterations in the immune cell landscape in response to viral infection. BD Biosciences has a broad catalog of flow cytometry reagents to aid in the analysis and isolation of cells of the innate and adaptive immune system.

For example, T cells are a key component of viral immunity, not only indirectly fighting viral infections, but also in helping to mount a successful antibody response to provide lasting immunity. The table below shows a representative list of high-quality, flow cytometry–tested antibodies available in a broad range of colors that enable a comprehensive study of murine and human T cell biology.

Type of Cell CD8+ Cytotoxic T Lymphocytes (CTLs) CD8+ Exhausted CTLs CD4+ Th1 CD4+ Th17 CD4+ Tfh CD4+ Tregs
Main Function Kill virus-infected cells Activated but have lost cytotoxic activity Promote cell-mediated response Enhance neutrophil and macrophage recruitment Regulate development of antigen
specific B cell development and
antibody production
Immune regulation
Pathogens Targeted Viruses and some intracellular pathogens Intracellular pathogens Extracellular pathogens
Extracellular Markers CD8 CD279 (PD-1)
CD152 (CTLA-4)
CD223 (LAG-3)
CD366 (TIM-3)
TIGIT
CD159a (NKG2A)
CD4
CD183 (CXCR3)
CD4
CD196 (CCR6)
CD4
CD185 (CXCR5)
CD4
CD25
Differentiation Cytokines IFN-γ
IL-2
IL-12
TGF-β
IL-6
IL-21
IL-12
IL-6
TGF-β
IL-12
Hallmark Cytokines IFN-γ
TNF
IL-2
IFN-γ
TNF
IL-2
IL-17A
IL-17F
IL-21
TNF
IL-21 TGF-β
IL-10
Transcription Factors Eomes IRF4 T-bet
Stat1
Stat6
RORγt Bcl-6
MAF
FoxP3
Smad3
Stat5

BD Horizon™ Dri Chroma Panels

BD offers contract manufacturing of pre-aliquoted, performance-optimized multicolor panels for flow cytometry in a dried down, ready to use format. The dried multicolor panels reduce inter-experiment variability and come with long shelf lives making them ideal choices for multisite and longitudinal studies.

Learn More

Cytokine Response

Proper cytokine response is important for the clearance of any virus. In the case of COVID-19, early research suggests that overactive responses leading to cytokine release syndrome may contribute to more severe presentation of the disease1, 2. Some cytokines that have been identified as abnormally high in COVID-19 samples include:

BD Biosciences offers different solutions for comprehensive measurement of cytokine production, either at the single-cell (intracellular flow cytometry, BD FastImmune™ Cytokine Detection System) or bulk level (BD® Cytometric Bead Array, ELISA) for COVID-19 research.

BD FastImmune™ Cytokine Detection System

With streamlined and highly reproducible intracellular cytokine staining, the BD FastImmune System is designed to meet the needs of applied research on human samples. As a complete and optimized system, it is particularly well suited for research studies assessing immune responses to virus or vaccine candidates.

BD Biosciences provides a range of BD FastImmune Multicolor or Single-Color Cytokine Reagents, produced under RUO (GMP) conditions, for antibody staining, including selected sample-activation and sample-processing reagents. 

Available Cocktails:

Selected list of relevant single-color BD FastImmune Reagents for analysis of cytokine and degranulation marker expression.

Target APC FITC PE Activating Reagents
CD107a
CD2/CD2R
CD28/CD49d Costimulatory Reagent
IFN-γ
IL-13
IL-1ra
IL-1α
IL-1β
IL-2
IL-4
IL-6
IL-8
TNF

BD? Cytometric Bead Array (CBA)

BD® CBA solutions are available in preconfigured kits or in an open, configurable format for unique needs.

BD CBA Flex Sets provide an open and configurable method of detection so that researchers can build their own multiplexes for protein quantitation as low as 10 pg/mL.

BD CBA Enhanced Sensitivity Flex Sets are capable of detecting cytokine concentrations as low as 0.274 pg/mL.

BD CBA Kits are preconfigured for achieving consistent results for routine panels.

Selected list of relevant BD CBA Flex Sets:

ELISAs

BD Biosciences offers three convenient ELISA reagent formats for quantitation of cytokines and other soluble proteins.

Individual reagents are comprised of unlabeled capture antibodies, biotinylated detection antibodies and protein standards offering a wide range of specificities and assay design flexibility. BD OptEIA™ Sets include reagents for five or twenty 96-well plates and pre-coated 96-well plates. All three BD Biosciences sandwich ELISA formats provide fast, easy quantitation of soluble analytes and total response analysis.

Selected list of relevant BD OptEIA™ ELISA Sets:

BD® AbSeq Antibodies

Utilize the cutting-edge antibody-oligo technology in the form of BD AbSeq Antibodies to probe up to 100 different cell surface proteins at a single-cell level, while simultaneously performing single-cell RNA analyses. Multiomic research using BD AbSeq Antibodies enables deeper characterization of your immune populations of interest and the potential discovery of novel cell immune signatures.

References

  1. Shi Y, Wang Y, Shao C, et al. COVID-19 infection: the perspectives on immune responses. Cell Death Differ. 2020; Epub ahead of print. doi: 10.1038/s41418-020-0530-3.
  2. Cossarizza A, De Biasi S, Guaraldi G, Girardis M, Mussini C. SARS-CoV-2, the virus that causes COVID-19: cytometry and the new challenge for global health. Cytometry A. 2020;97(4):340–343. doi: 10.1002/cyto.a.24002.

Instrument Solutions

Cell Analyzers

Flow cytometry has been a common approach to analyze cells and sort them to near-purity for decades, and more recently, the analysis of small entities such as virus and exosomes have become more mainstream. BD Biosciences portfolio of cell analyzers offers the solutions necessary for your COVID-19 related research experiments.

BD FACSCelesta? Flow Cytometer

BD FACSCelesta™

The BD FACSCelesta Flow Cytometer is designed to make high-performance, multicolor flow cytometry accessible to individual labs analyzing up to 14 parameters. Drive your fundamental research in viral immune response forward without waiting for the core lab.

Learn More


BD FACSLyric? Flow Cytometer

BD FACSLyric™

The BD FACSLyric Flow Cytometer is an IVD instrument and can be used in research as well. Upgradeable from 4 to 12 colors, the BD FACSLyric Flow Cytometer offers high resolution and simplified standardization across instruments and labs, enabling collaboration and accelerating translational research. These make the BD FACSLyric Flow Cytometer a powerful tool for COVID-19 research. For more information on the BD FACSLyric Flow Cytometer contact your local representative.


BD FACSymphony? Cell Analyzer

BD FACSymphony™

Offering customized solutions for high-parameter analysis, the BD FACSymphony Cell Analyzers can scale up to meet your multicolor needs. When your SARS-CoV-2 research relies on either broad or deep high-parameter phenotypic characterization of specific subpopulations of immune cells, rely on the BD FACSymphony Analyzer.

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Cell Sorters

BD has led the way for 40 years in cell sorting. BD sorters combined with custom biosafety cabinets with integrated aerosol management systems from The Baker Company have been verified to provide product and personnel protection according to several bioprotection standards. In addition, the BD FACSAria™ product family and BD FACSymphony™ S6 Containment Systems have been verified using the recommended Cyclex-d/Dragon Green microsphere assay1. Information about a new SARS-CoV-2 sorting protocol is available at the ISAC Biosafety website.


BD FACSMelody? Cell Sorter

BD FACSMelody™

A truly easy-to-use cell sorter for your own lab, the BD FACSMelody makes the complex world of flow cytometry and sorting available to more researchers. It combines proven BD technology with new automation and simplified software to deliver high-performance results in less time. The BD FACSMelody Cell Sorter provides an easy solution for purification of immune cells of interest for downstream functional or multiomic assays for research use.

Learn More


BD FACSAria? Fusion Cell Sorter

BD FACSAria™ Fusion

The BD FACSAria Fusion Cell Sorter delivers exceptional multicolor performance and ease-of-use, combined with best-in-class biosafety expertise for an advanced cell sorter and biosafety solution. Purification of antigen-specific T and B cells for downstream functional assays is a major application in vaccine research, and the BD FACSAria Fusion Cell Sorter is built to deliver on this front.

Learn More


BD FACSymphony? S6 Cell Sorter

BD FACSymphony™ S6

Building on the BD FACSAria Fusion biosafety solution, the BD FACSymphony S6 Cell Sorter adds high-parameter analysis to isolate populations based on more than 20 parameters and 6-way sorting capabilities to isolate more populations from one precious sample. Transfer panels from the BD FACSymphony A5 Cell Analyzer to isolate ultraspecific immune cell subpopulations with complex phenotypes in order to research antigen–specific cell subsets.

Learn More

Single-Cell Multiomics

BD Rhapsody™ Single-Cell Analysis System

BD Rhapsody™ Single-Cell Analysis System

Perform multiomic analyses by probing protein and RNA information of immune cells simultaneously. Utilize BD Rhapsody’s multiomic data to discover novel immune subsets and study in depth the molecular drivers of immune cell activation and exhaustion in response to viral infection. You can also perform T and B cell receptor repertoire analysis that could potentially enable identification and tracking of vaccine-specific clonotypes expanded upon vaccination or discovery of novel immune cell types responding to infection.

Learn More

Additional Instrument Information

This additional instrument-related information may be helpful to you or your lab during this time. Please see the Support tab for contact information for any additional questions.

Reference

  1. Perfetto SP, Hogarth PJ, Monard S, et al. Novel impactor and microsphere-based assay used to measure containment of aerosols generated in a flow cytometer cell sorter. Cytometry A. 2019;95(2):173–182. doi: 10.1002/cyto.a.23680.

Data Analysis

BD Biosciences offers powerful informatics tools to complement your flow cytometry and multiomic analysis. These workflows are used by scientists in the lab to enable data insights in infectious disease and vaccine research. Supporting research is our top priority. In response to the increased need to work remotely and to limit time spent in laboratories during this pandemic, we are temporarily offering our users special remote access to FlowJo™ Software to ensure your important research analysis can continue.

Learn More


FlowJo? Software flow cytometry data analysis

Flow Cytometry Analysis

FlowJo™ Software is the leading platform for single-cell flow cytometry analysis that helps your research stand out with accessible features for immunophenotyping, cell cycle, proliferation, kinetics studies, quantitative population comparison, plate screening assays and more.

Learn More


SeqGeq Software RNA-Seq and single-cell RNA data analysis

RNA-Seq Analysis

SeqGeq™ Software v1.6 analyzes data from RNA-Seq and single-cell RNA-Seq experiments, providing tools to extract genes and cells of interest and putting transcriptome analyses back in the hands of bench scientists. Explore, visualize and shape your next-gen sequencing data with interactive graphing tools that are designed to help you focus on the insights that matter most.

Learn More

We offer a variety of support and training for when you need it most:

More Information

    For information on BD’s comprehensive COVID-19 response efforts—including product availability, status of BD operations and business continuity planning—visit bd.com/COVID-19

    To enable principal investigators in basic and translational research labs to obtain answers to key scientific questions, BD Biosciences has established a multi-disciplinary COVID-19 response team. Comprising of BD application specialists in flow cytometry and Multi-Omics, this team will provide researchers with technical support and knowhow to gain insights into important scientific aspects of COVID-19 virology.

    Learn More


    Remote Support: BD Assurity Linc™ Remote Systems Management Software

    In times of limited onsite interactions due to COVID-19 restrictions, BD has reinforced its remote support capabilities. BD Assurity Linc™ Remote Services, now powered by BD’s RSS technology, provides remote access into BD systems, allowing BD Service and Support teams to monitor your instruments and address technical issues remotely in a timely manner.

    Enjoy the benefits of reduced service visits, faster issue resolution and high-level security.

    If you are interested in installing this software or learning more, please contact [email protected].

    Customer Service

    European Support

    [email protected] 

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